Details

Autor(en) / Beteiligte

• Grob, U
• Krass, M. D
• Héritier, M
• Pachlatko, R
• Rhensius, J
• Košata, J
• Moores, B. A
• Takahashi, H
• Eichler, A
• Degen, C. L

Titel

Magnetic Resonance Force Microscopy with a One-Dimensional Resolution of 0.9 Nanometers

Ist Teil von

• Nano letters, 2019-11, Vol.19 (11), p.7935-7940

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Magnetic resonance force microscopy (MRFM) is a scanning probe technique capable of detecting MRI signals from nanoscale sample volumes, providing a paradigm-changing potential for structural biology and medical research. Thus far, however, experiments have not reached sufficient spatial resolution for retrieving meaningful structural information from samples. In this work, we report MRFM imaging scans demonstrating a resolution of 0.9 nm and a localization precision of 0.6 nm in one dimension. Our progress is enabled by an improved spin excitation protocol furnishing us with sharp spatial control on the MRFM imaging slice, combined with overall advances in instrument stability. From a modeling of the slice function, we expect that our arrangement supports spatial resolutions down to 0.3 nm given sufficient signal-to-noise ratio. Our experiment demonstrates the feasibility of subnanometer MRI and realizes an important milestone toward the three-dimensional imaging of macromolecular structures.