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Magnetic Resonance Force Microscopy with a One-Dimensional Resolution of 0.9 Nanometers
Ist Teil von
Nano letters, 2019-11, Vol.19 (11), p.7935-7940
Ort / Verlag
United States: American Chemical Society
Erscheinungsjahr
2019
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Magnetic resonance force microscopy (MRFM) is a scanning probe technique capable of detecting MRI signals from nanoscale sample volumes, providing a paradigm-changing potential for structural biology and medical research. Thus far, however, experiments have not reached sufficient spatial resolution for retrieving meaningful structural information from samples. In this work, we report MRFM imaging scans demonstrating a resolution of 0.9 nm and a localization precision of 0.6 nm in one dimension. Our progress is enabled by an improved spin excitation protocol furnishing us with sharp spatial control on the MRFM imaging slice, combined with overall advances in instrument stability. From a modeling of the slice function, we expect that our arrangement supports spatial resolutions down to 0.3 nm given sufficient signal-to-noise ratio. Our experiment demonstrates the feasibility of subnanometer MRI and realizes an important milestone toward the three-dimensional imaging of macromolecular structures.
Sprache
Englisch
Identifikatoren
ISSN: 1530-6984
eISSN: 1530-6992
DOI: 10.1021/acs.nanolett.9b03048
Titel-ID: cdi_proquest_miscellaneous_2309492053
Format
–
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