Details

Autor(en) / Beteiligte

• Deng, Tian
• Zhao, Hao
• Shi, Miusi
• Qiu, Yun
• Jiang, Shuting
• Yang, Xiangliang
• Zhao, Yanbing
• Zhang, Yufeng

Titel

Photoactivated Trifunctional Platinum Nanobiotics for Precise Synergism of Multiple Antibacterial Modes

Ist Teil von

• Small (Weinheim an der Bergstrasse, Germany), 2019-11, Vol.15 (46), p.e1902647-n/a

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2019

Quelle

Wiley Online Library

Beschreibungen/Notizen

• Integrating multiple strategies of antibacterial mechanisms into one has been proven to have tremendous promise for improving antimicrobial efficiency. Hence, dual‐valent platinum nanoparticles (dvPtNPs) with a zero‐valent platinum core (Pt0) and bi‐valent platinum shell (Pt2+ ions), combining photothermal and photodynamic therapy, together with “chemotherapy,” emerge as spatiotemporally light‐activatable platinum nano‐antibiotics. Under near‐infrared (NIR) exposure, the multiple antibacterial modes of dvPtNPs are triggered. The Pt0 core reveals significant hyperthermia via effective photothermal conversion while an immediate release of chemotherapeutic Pt2+ ions occurs through hyperthermia‐initiated destabilization of metallic interactions, together with reactive oxygen species (ROS) level increase, thereby resulting in synergistic antibacterial effects. The precise cooperative effects between photothermal, photodynamic, and Pt2+ antibacterial effects are achieved on both Gram‐negative Escherichia coli and Gram‐positive methicillin‐resistant Staphylococcus aureus, where bacterial viability and colony‐forming units are significantly reduced. Moreover, similar results are observed in mice subcutaneous abscess models. Significantly, after NIR treatment, dvPtNP exhibits a more robust bacteria‐killing efficiency than other PtNP groups, owing to its integration of dramatic damage to the bacterial membrane and DNA, and alteration to ATP and ROS metabolism. This study broadens the avenues for designing and synthesizing antibacterial materials with higher efficiency. When dual‐valent platinum nanoparticles (dvPtNPs) are activated by near‐infrared irradiation, precise cooperation of multiple antibacterial modes occurs. The photothermal effect leads to the bacterial membrane perforation and RNA leakage, and owing to the photodynamic effect, the ROS level rises up while ATP level declines. Moreover, Pt2+ ions release as “chemotherapy” resulting in DNA damage and bacterial growth inhibition.