Details

Autor(en) / Beteiligte

• Dai, Lei
• Xia, Zi‐Hao
• Gao, Yuan‐Yuan
• Gao, Zhong‐Hua
• Ye, Song

Titel

Visible‐Light‐Driven N‐Heterocyclic Carbene Catalyzed γ‐ and ϵ‐Alkylation with Alkyl Radicals

Ist Teil von

• Angewandte Chemie International Edition, 2019-12, Vol.58 (50), p.18124-18130

Auflage

International ed. in English

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The merging of photoredox catalysis and N‐heterocyclic carbene (NHC) catalysis for γ‐ and ϵ‐alkylation of enals with alkyl radicals was developed. The alkylation reaction of γ‐oxidized enals with alkyl halides worked well for the synthesis γ‐multisubstituted‐α,β‐unsaturated esters, including those with challenging vicinal all‐carbon quaternary centers. The synthesis of ϵ‐multisubstituted‐α,β‐γ,δ‐diunsaturated esters by an unprecedented NHC‐catalyzed ϵ‐functionalization was also established. A merger: The merging of photoredox catalysis and N‐heterocyclic carbene (NHC) catalysis for γ‐ and ϵ‐alkylation of enals with alkyl halides was developed, giving the corresponding γ‐substituted α,β‐unsaturated esters and ϵ‐substituted α,β‐γ,δ‐diunsaturated esters exclusively in good yields.