Epigenomics, 2019-11, Vol.11 (14), p.1561-1579
2019
Details
- Autor(en) / Beteiligte
- Titel
- Epigenetic identification of ADCY4 as a biomarker for breast cancer: an integrated analysis of adenylate cyclases
- Ist Teil von
- Epigenomics, 2019-11, Vol.11 (14), p.1561-1579
- Ort / Verlag
- England: Future Medicine Ltd
- Erscheinungsjahr
- 2019
- Link zum Volltext
- Quelle
- Taylor & Francis Journals Auto-Holdings Collection
- Beschreibungen/Notizen
- To explore the role of adenylyl cyclase isoforms and its epigenetics in cancer. Adenylyl cyclase expression profiles, epigenetic alterations, prognostic value and molecular networks were assessed by use of public omics datasets. was significantly downregulated in breast cancer. This downregulation was associated with promoter hypermethylation. High expression was correlated with better survival of patients with breast cancer and its different intrinsic subtypes and tumor stages. ADCY4 was shown to be strongly associated with G protein coupled receptors and the downstream cAMP signaling pathway, which was also significantly enriched in newly identified lysophosphatidic acid receptor 4 and glucagon-like peptide-1. ADCY4 may be used as an epigenetic biomarker for breast cancer, as well as a possible target for therapy.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1750-1911eISSN: 1750-192XDOI: 10.2217/epi-2019-0207Titel-ID: cdi_proquest_miscellaneous_2301430046
- Format
- –
- Schlagworte
- Adenylate cyclase, adenylyl cyclases, Adenylyl Cyclases - genetics, biomarker, Biomarkers, Biomarkers, Tumor - genetics, Breast cancer, Breast Neoplasms - genetics, Breast Neoplasms - pathology, cAMP signaling pathway, Colorectal cancer, Datasets, Deoxyribonucleic acid, DNA, DNA methylation, DNA Methylation - genetics, Down-Regulation - genetics, Epigenesis, Genetic - genetics, Epigenetics, Epigenomics - methods, Female, G protein-coupled receptor, G protein-coupled receptors, Gastric cancer, Gene expression, Genomics, Glucagon, Glucagon-like peptide 1, Humans, Isoforms, Liver cancer, Lung cancer, Lysophosphatidic acid, lysophosphatidic acid receptor, Medical prognosis, Mortality, Prognosis, Promoter Regions, Genetic - genetics, Receptors, Receptors, G-Protein-Coupled - genetics, Signal transduction, Signal Transduction - genetics, Survival analysis, Tumorigenesis, Web portals