Details

Autor(en) / Beteiligte

• Xu, Ke
• Li, Wenchang
• Zhu, Shaoheng
• Zhu, Tingshun

Titel

Atroposelective Arene Formation by Carbene‐Catalyzed Formal [4+2] Cycloaddition

Ist Teil von

• Angewandte Chemie International Edition, 2019-12, Vol.58 (49), p.17625-17630

Auflage

International ed. in English

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Atroposelective arene formation is an efficient method to build axially chiral molecules with multi‐substituted arenes. Reported here is an organocatalyzed atroposelective arene formation reaction by an N‐heterocyclic carbene (NHC) catalyzed formal [4+2] cycloaddition of conjugated dienals and α‐aryl ketones. This study expands the synthetic potential of NHC organocatalysis and provides a competitive pathway for the synthesis of axially chiral ligands, catalysts, and other functional molecules. Atroposelective [4+2]: A new organocatalyzed atroposelective arene formation reaction involves a carbene‐catalyzed formal [4+2] cycloaddition of conjugated enals and α‐aryl ketones. This study expands the synthetic potential of N‐heterocyclic carbene (NHC) organocatalysis and provides a competitive pathway for the synthesis of axially chiral ligands, catalysts, and other functional molecules.