European biophysics journal, 2019-12, Vol.48 (8), p.721-729
2019
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Details
- Autor(en) / Beteiligte
- Titel
- Effects of bovine serum albumin (BSA) on the excited-state properties of meso-tetrakis(sulfonatophenyl) porphyrin (TPPS4)
- Ist Teil von
- European biophysics journal, 2019-12, Vol.48 (8), p.721-729
- Ort / Verlag
- Cham: Springer International Publishing
- Erscheinungsjahr
- 2019
- Quelle
- SpringerLink
- Beschreibungen/Notizen
- To infer changes in the photophysical properties of porphyrins due to complexation with albumin, a combination of Z -scan and conventional spectroscopic techniques was employed. We measured the characteristics of excited states of meso -tetrakis(sulfonatophenyl) porphyrin bound to bovine serum albumin and observed that the binding reduces the intersystem crossing quantum yield and increases the internal conversion one. A reverse saturable absorption process was observed in the nanosecond timescale. These results are important for prediction of the efficiency of this complex in medical and optical applications, because associating porphyrins to proteins enables better accumulation in tumors and improves its stability in optical devices, but at the same time, decreases its triplet quantum yield.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0175-7571eISSN: 1432-1017DOI: 10.1007/s00249-019-01397-wTitel-ID: cdi_proquest_miscellaneous_2296659792
- Format
- –
- Schlagworte
- Animals, Biochemistry, Biological and Medical Physics, Biomedical and Life Sciences, Biophysics, Bovine serum albumin, Cattle, Cell Biology, Excitation, Internal conversion, Life Sciences, Membrane Biology, Nanotechnology, Neurobiology, Original Article, Porphyrins, Porphyrins - chemistry, Porphyrins - metabolism, Protein Binding, Serum albumin, Serum Albumin, Bovine - metabolism, Spectrometry, Fluorescence, Thermodynamics, Tumors