Details

Autor(en) / Beteiligte

• Hughes, Samantha
• Celikel, Tansu

Titel

Prominent Inhibitory Projections Guide Sensorimotor Computation: An Invertebrate Perspective

Ist Teil von

• BioEssays, 2019-10, Vol.41 (10), p.e1900088-n/a

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2019

Quelle

Wiley Online Library All Journals

Beschreibungen/Notizen

• From single‐cell organisms to complex neural networks, all evolved to provide control solutions to generate context‐ and goal‐specific actions. Neural circuits performing sensorimotor computation to drive navigation employ inhibitory control as a gating mechanism as they hierarchically transform (multi)sensory information into motor actions. Here, the focus is on this literature to critically discuss the proposition that prominent inhibitory projections form sensorimotor circuits. After reviewing the neural circuits of navigation across various invertebrate species, it is argued that with increased neural circuit complexity and the emergence of parallel computations, inhibitory circuits acquire new functions. The contribution of inhibitory neurotransmission for navigation goes beyond shaping the communication that drives motor neurons, and instead includes encoding of emergent sensorimotor representations. A mechanistic understanding of the neural circuits performing sensorimotor computations in invertebrates will unravel the minimum circuit requirements driving adaptive navigation. All animals use sensorimotor integration to generate context‐specific actions, and independent of the organism, inhibitory neurons powerfully shape the motor control during sensorimotor computation. Essential sensorimotor circuit properties observed in complex animals (e.g., the fly and mammals) are conserved in organisms with more compact circuitry, such as the nematode.