Details

Autor(en) / Beteiligte

• Záveský, Luděk
• Jandáková, Eva
• Weinberger, Vít
• Minář, Luboš
• Hanzíková, Veronika
• Dušková, Daniela
• Drábková, Lenka Záveská
• Hořínek, Aleš

Titel

Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers

Ist Teil von

• Cancer investigation, 2019-10, Vol.37 (9), p.440-452

Ort / Verlag

Taylor & Francis

Erscheinungsjahr

2019

Link zum Volltext

Beschreibungen/Notizen

• Ovarian cancer is the deadliest gynecologic cancer. The large-scale microRNA (miRNA) expression profiling and individual miRNA validation was performed to find potential novel biomarkers for ovarian cancer. The most consistent overexpression of miRs-200b-3p, 135 b-5p and 182-5p was found in both ascitic fluid and tumors and suggests their potential as oncogenes. miR-451a was consistently underexpressed so may be a tumor suppressor. Results were inconsistent for miR-204-5p, which was overexpressed in ascitic fluid but underexpressed in tumor tissue. miR-203a-3p was generally overexpressed but this failed to be proved in independent sample set in tissue validation.