Details

Autor(en) / Beteiligte

• Pichi, Francesco
• Invernizzi, Alessandro
• Tucker, William R.
• Munk, Marion R.

Titel

Optical coherence tomography diagnostic signs in posterior uveitis

Ist Teil von

• Progress in retinal and eye research, 2020-03, Vol.75, p.100797-100797, Article 100797

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• A diagnostic sign refers to a quantifiable biological parameter that is measured and evaluated as an indicator of normal biological, pathogenic, or pharmacologic responses to a therapeutic intervention. When used in translational research discussions, the term itself often alludes to a sign used to accelerate or aid in diagnosis or monitoring and provide insight into “personalized” medicine. Many new diagnostic signs are being developed that involve imaging technology. Optical coherence tomography is an imaging technique that provides in vivo quasi-histological images of the ocular tissues and as such it's able to capture the structural and functional modifications that accompany inflammation and infection of the posterior part of the eye. From the hyperreflective inflammatory cells and deposits in the vitreous and on the hyaloid, to the swollen photoreceptors bodies in multiple evanescent white dots syndrome, and from optical differences in the subretinal fluid compartments in Vogt-Koyanagi-Harada disease to the hyporeflective granulomas in the choroid, these tomographical signs can be validated to reach the status of biomarkers. Such non-invasive imaging diagnostic signs of inflammation can be very useful to clinicians seeking to make a diagnosis and can represent a dataset for machine learning to offer a more empirical approach to the detection of posterior uveitis. •A biomarker is a measurable indicator of the presence of some disease state.•Optical coherence tomography biomarkers have many advantages for the uveitis patients.•OCT biomarkers in uveitis are usually noninvasive, and they produce intuitive, multidimensional results.•Yielding both qualitative and quantitative data, they are usually relatively comfortable for patients.•When combined with other sources of information, they can be very useful to clinicians seeking to make a diagnosis.