Details

Autor(en) / Beteiligte

• Gunduz, Mehmet
• Okan, Meliha A.
• Sengil, Ahmet Z.
• Temel, Hayrettin
• Comert, Murat
• Okur, Mesut

Titel

The relationship of argyrophilic proteins of the nuclear‐organized regions and atopic dermatitis in children

Ist Teil von

• Experimental dermatology, 2019-11, Vol.28 (11), p.1309-1312

Ort / Verlag

Denmark: Wiley Subscription Services, Inc

Erscheinungsjahr

2019

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Background The argyrophilic proteins of nuclear‐organized regions (AgNOR), visualised with colloidal silver methods as black dots are known as AgNOR. To date, the relationship between AgNOR and cancer and inflammatory conditions has been investigated. However, there has been no report investigating the relationship between AgNOR and atopic dermatitis. The aim of this study was to investigate the relationship between atopic dermatitis and AgNOR in paediatric patients. Methods Twenty‐nine children with atopic dermatitis and 23 healthy children were included in the study. AgNOR test results were analysed prospectively. Results The mean AgNOR number (40.19 ± 21.06) in the patient group was significantly higher than the control group (12.83 ± 10.40) (P < .001). Conclusions This study investigated the association between AgNOR and atopic dermatitis for the first time in the literature. In the study, atopic dermatitis and AgNOR were found to be related. In the study, for the first time with the ROC analysis, AgNOR limit values with high sensitivity and specificity levels were determined in the diagnosis of atopic dermatitis.