Details

Autor(en) / Beteiligte

• Yang, Pei
• Qian, Fei‐Ya
• Zhang, Ming‐Fei
• Xu, A‐Lan
• Wang, Xiang
• Jiang, Bao‐Ping
• Zhou, Ling‐Ling

Titel

Th17 cell pathogenicity and plasticity in rheumatoid arthritis

Ist Teil von

• Journal of leukocyte biology, 2019-12, Vol.106 (6), p.1233-1240

Ort / Verlag

United States

Erscheinungsjahr

2019

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• CD4+ Th cells play an important role in the development of rheumatoid arthritis (RA) by regulating adaptive immune response. As major subsets of CD4+ Th cells, Th17 cells can produce a large number of hallmark cytokines such as IL‐17A and IL‐17F, which participate in host defense and immune homeostasis. However, increasing researches have shown that Th17 cells are unstable and exhibit a certain degree of plasticity, which aggravates their pathogenicity. Furthermore, the plasticity and pathogenicity of Th17 cells are closely related with the disease activity in RA. In this paper, the characteristics including phenotype, differentiation, plasticity, and pathogenicity of Th17 cells in RA will be systematically summarized. This will contribute to clarify the immunologic mechanism of RA and further provide a novel strategy for the clinical treatment of autoimmune diseases. Review on Th17 cell plasticity in rheumatoid arthritis, including its immunological mechanism and potential implications for the clinical treatment of RA.