Details

Autor(en) / Beteiligte

• Calatayud, Marta
• Koren, Omry
• Collado, Maria Carmen

Titel

Maternal Microbiome and Metabolic Health Program Microbiome Development and Health of the Offspring

Ist Teil von

• Trends in endocrinology and metabolism, 2019-10, Vol.30 (10), p.735-744

Ort / Verlag

United States: Elsevier Ltd

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Maternal nutritional, metabolic, and physiological states, as well as exposure to various environmental factors during conception, gestation, and lactation, have a fundamental role in the health programming of the offspring. Therefore, alterations affecting the maternal microbiota might indirectly influence fetal development. In addition, such alterations could be transmitted to the progeny at different stages of infant development (e.g., preconception, prenatal, or postnatal), thereby favoring the development of an altered microbiota in the neonate. Microbial changes of this kind have been linked to an increased risk of non-communicable diseases (NCDs), including obesity and metabolic syndrome, allergy-related problems, and diabetes. In this review, we summarize the relevance of the maternal microbiota to fetal–neonatal health programming, with a focus on maternal nutritional and metabolic states. Shifts in the maternal microbiota could influence fetal development, in addition to being transmitted to the newborn during birth and lactation.Alterations in microbial colonization patterns are linked to an increased risk of NCDs, such as obesity, diabetes, and allergies.The delivery mode, nutritional status of the mother, and perinatal environmental exposures all impact the gut microbiota, thereby affecting the nutritional and metabolic status of the host.Maternal metabolic status and diet during pregnancy have a key impact on both the maternal and infant microbiota, although the detailed effects remain obscure.