Details

Autor(en) / Beteiligte

• Martins, Patricia P.
• Smyth, Hugh D.C.
• Cui, Zhengrong

Titel

Strategies to facilitate or block nose-to-brain drug delivery

Ist Teil von

• International journal of pharmaceutics, 2019-10, Vol.570, p.118635-118635, Article 118635

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2019

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• [Display omitted] Nose-to-brain delivery has gained significant interest over the past several decades. This has resulted in numerous strategies described to improve the delivery of drugs to the brain directly through the olfactory epithelium of the nasal cavity. In some cases, intranasal administration may be more effective than other routes of administration in treating central nervous system and related disorders. Here, we briefly review the strategies that have been used to facilitate nose-to-brain delivery as well as approaches to block the delivery of drugs from the nose to the brain. Even though numerous strategies have already been used to increase nose-to-brain delivery, the research for strategies inhibitory of nose-to-brain delivery seems to be scarce.