Details

Autor(en) / Beteiligte

• Zegher, Francis
• Malpique, Rita
• Garcia‐Beltran, Cristina
• Ibáñez, Lourdes

Titel

Towards a simple marker of hepato‐visceral adiposity and insulin resistance: The Z‐score change from weight‐at‐birth to BMI‐in‐childhood

Ist Teil von

• Pediatric obesity, 2019-10, Vol.14 (10), p.e12533-n/a

Ort / Verlag

England: Wiley Subscription Services, Inc

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• Summary Background Insulin resistance and hepato‐visceral (central) fat excess are thought to contribute to an earlier timing of adrenarche/pubarche and puberty/menarche; this earlier timing in turn relates often to a mismatch between prenatal and postnatal weight gain, which can be estimated by calculating the Z‐score change from birth weight (BW) to body mass index (BMI) in childhood. Methods We tested the hypothesis that this calculation may serve as a proxy of insulin resistance and hepato‐visceral adiposity in prepuberty by reappraising a cohort of children (mean age, 8.5 years), born appropriate‐ (AGA, n = 41) or small‐for‐gestational age (SGA, n = 45), followed since birth (n = 76) or since the age of 3 years (n = 10). Assessments included anthropometry; fasting glucose and insulin; liver volume; and hepatic fat, subcutaneous fat, and visceral fat in the abdominal region (by magnetic resonance imaging [MRI]). Results Z‐score change BW‐BMI closely associated to central fat (R = 0.74; P < .0001) and insulin resistance (R = 0.71; P < .0001). Conclusion These results suggest that Z‐score change BW‐BMI could be viewed as a simple candidate‐marker for hepato‐visceral adiposity and insulin resistance in prepubertal children.