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Curcumin analogues and their hybrid molecules as multifunctional drugs
Ist Teil von
European journal of medicinal chemistry, 2019-11, Vol.182, p.111631-111631, Article 111631
Ort / Verlag
France: Elsevier Masson SAS
Erscheinungsjahr
2019
Link zum Volltext
Quelle
Elsevier ScienceDirect Journals Complete
Beschreibungen/Notizen
Curcumin (diferuloylmethane or 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) is an interesting compound that is characterized by a special chemical structure with a diversified biological and pharmaceutical properties. A huge number of studies have explored the medicinal properties of curcumin, including antitumoral, antimicrobial, anti-inflammatory, antioxidant, antihepatotoxic, antihyperlipidemic, antiviral, and anti-Alzheimer's disease effects. Despite its range of reported pharmacological effects, it has poor bioavailability during oral administration and poor solubility and so, it is limited in its clinical applicability. Therefore, several strategies were developed to overcome this disadvantage, such as nanoparticle and formulations in liposomal, micellar or phospholipid complex. One of the most common strategies is the design and synthesis of new curcumin derivatives and analogues that have better therapeutic properties and bioavailability where great efforts have been made by scientists in this field. Thus, the scope of this review is to report the up-to-date synthesized derivatives, analogues and to classify them according to their chemical structure. The review sheds light on the most important and potent compounds where several effective moieties are introduced into different positions so as to be suitable for different biological activities. Additionally, an interesting class of curcumin hybrids and the synergy that would be expected based on their chemical structures are also covered in this review. Also, the structure-activity relationship of several analogues and some selected examples of patents on curcumin analogues were displayed.
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•Curcumin, the well-known traditional medicine, continues to inspire researchers.•This review covers the recent advances of curcumin analogues and their hybrids as multifunctional drugs.•The first part of the review classifies the newly synthesized curcumin analogues and focuses on the most important analogues.•The second part of the review provides efficient synthetic methods for curcumin hybrids and their biological properties.•Hybridization of curcumin with several bioactive molecules allowing synergy in many cases.