Details

Autor(en) / Beteiligte

• Miyagawa, Toji
• Brushaber, Danielle
• Syrjanen, Jeremy
• Kremers, Walter
• Fields, Julie
• Forsberg, Leah K.
• Heuer, Hilary W.
• Knopman, David
• Kornak, John
• Boxer, Adam
• Rosen, Howie
• Boeve, Bradley
• Appleby, Brian
• Bordelon, Yvette
• Bove, Jessica
• Brannelly, Patrick
• Caso, Christina
• Coppola, Giovanni
• Dever, Reilly
• Dheel, Christina
• Dickerson, Bradford
• Dickinson, Susan
• Dominguez, Sophia
• Domoto-Reilly, Kimiko
• Faber, Kelley
• Ferrell, Jessica
• Fishman, Ann
• Fong, Jamie
• Foroud, Tatiana
• Gavrilova, Ralitza
• Gearhart, Debra
• Ghazanfari, Behnaz
• Ghoshal, Nupur
• Goldman, Jill S.
• Graff-Radford, Jonathan
• Graff-Radford, Neill
• Grant, Ian
• Grossman, Murray
• Haley, Dana
• Hsiung, Robin
• Huey, Edward
• Irwin, David
• Jones, David
• Jones, Lynne
• Kantarci, Kejal
• Karydas, Anna
• Kaufer, Daniel
• Kerwin, Diana
• Kraft, Ruth
• Kramer, Joel
• Kukull, Walter
• Litvan, Irene
• Lucente, Diane
• Lungu, Codrin
• Mackenzie, Ian
• Maldonado, Miranda
• Manoochehri, Masood
• McGinnis, Scott
• McKinley, Emily
• Mendez, Mario F.
• Miller, Bruce
• Multani, Namita
• Onyike, Chiadi
• Padmanabhan, Jaya
• Pantelyat, Alexander
• Pearlman, Rodney
• Petrucelli, Leonard
• Potter, Madeline
• Rademakers, Rosa
• Ramos, Eliana M.
• Rankin, Kate
• Rascovsky, Katya
• Roberson, Erik D.
• Rogalski, Emily
• Sengdy, Pheth
• Shaw, Leslie
• Tartaglia, Maria C.
• Tatton, Nadine
• Taylor, Joanne
• Toga, Arthur
• Trojanowski, John Q.
• Wang, Ping
• Weintraub, Sandra
• Wong, Bonnie
• Wszolek, Zbigniew

Titel

Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium

Ist Teil von

• Alzheimer's & dementia, 2020-01, Vol.16 (1), p.79-90

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Behavior/Comportment/Personality (BEHAV) and Language (LANG) domains were added to the Clinical Dementia Rating (CDR®) for improving evaluation of patients with frontotemporal lobar degeneration (FTLD) (CDR® plus NACC FTLD). We analyzed the CDR® plus NACC FTLD among participants from the baseline visit of the Advancing Research and Treatment for Frontotemporal Lobar Degeneration/Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects Consortium. The CDR® plus NACC FTLD was able to detect early symptoms in the mildly impaired participants who were rated as CDR® sum of boxes (CDR®-SB) = 0. The CDR®-SB was not sensitive, particularly in participants with mild nonfluent/agrammatic primary progressive aphasia. Participants with familial and sporadic behavioral variant FTD exhibited similar CDR® plus NACC FTLD profiles except that language impairment was more frequent in participants with mild sporadic behavioral variant FTD. Adding the BEHAV and/or LANG domains to the CDR®-SB significantly enhanced discriminatory power in differentiating among the FTLD spectrum disorders. The BEHAV and LANG domains enable the CDR® plus NACC FTLD to capture early symptomatology of FTLD. •The CDR® plus NACC FTLD was completed at the baseline visit of the ARTFL/LEFFTDS Consortium.•The CDR® plus NACC FTLD captured early features of FTLD.•Sporadic and familial behavioral variant FTD were similar in most regards on the CDR® plus NACC FTLD.•Behavioral disturbance was often present in participants with semantic variant PPA.•Adding the Behavior and Language domains to the CDR® enhanced the discriminatory power.