Details

Autor(en) / Beteiligte

• Sherratt, Michael J.
• Hopkinson, Louise
• Naven, Mark
• Hibbert, Sarah A.
• Ozols, Matiss
• Eckersley, Alexander
• Newton, Victoria L.
• Bell, Mike
• Meng, Qing-Jun

Titel

Circadian rhythms in skin and other elastic tissues

Ist Teil von

• Matrix biology, 2019-11, Vol.84, p.97-110

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• Circadian rhythms are daily oscillations that, in mammals, are driven by both a master clock, located in the brain, and peripheral clocks in cells and tissues. Approximately 10% of the transcriptome, including extracellular matrix components, is estimated to be under circadian control. Whilst it has been established that certain collagens and extracellular matrix proteases are diurnally regulated (for example in tendon, cartilage and intervertebral disc) the role played by circadian rhythms in mediating elastic fiber homeostasis is poorly understood. Skin, arteries and lungs are dynamic, resilient, elastic fiber-rich organs and tissues. In skin, circadian rhythms influence cell migration and proliferation, wound healing and susceptibility of the tissues to damage (from protease activity, oxidative stress and ultraviolet radiation). In the cardiovascular system, blood pressure and heart rate also follow age-dependent circadian rhythms whilst the lungs exhibit diurnal variations in immune response. In order to better understand these processes it will be necessary to characterise diurnal changes in extracellular matrix biology. In particular, given the sensitivity of peripheral clocks to external factors, the timed delivery of interventions (chronotherapy) has the potential to significantly improve the efficacy of treatments designed to repair and regenerate damaged cutaneous, vascular and pulmonary tissues. •In mammals, circadian rhythms are controlled by a master clock in the brain and by peripheral clocks in cells and tissues.•Approximately 10% of transcripts appear to be under tissue-specific circadian control.•The influence of circadian rhythms on elastin and elastic fiber-associated proteins is poorly understood.•Chronotherapy, the timed application of treatment, has the potential to improve the efficacy of existing interventions.