Details

Autor(en) / Beteiligte

• Rabadia, Soniya V.
• Litvan, Irene
• Juncos, Jorge
• Bordelon, Yvette
• Riley, David E.
• Standaert, David
• Reich, Stephen G.
• Hall, Deborah A.
• Kluger, Benzi
• Shprecher, David
• Marras, Connie
• Jankovic, Joseph

Titel

Hypertension and progressive supranuclear palsy

Ist Teil von

• Parkinsonism & related disorders, 2019-09, Vol.66, p.166-170

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The epidemiologic evidence of whether hypertension is associated with Progressive Supranuclear Palsy (PSP) is inconsistent. The ENGENE-PSP case-control study determined various PSP risk factors including whether hypertension preceded PSP onset. Incident PSP cases per NINDS-PSP criteria and age-, sex-, race- matched controls were recruited from similar North American geographic areas. All study participants were administered standardized interviews to obtain data on demographics, medical history and medications. We used univariate and multivariate conditional logistic regression models to measure the associations between PSP and the following predictor variables: education level, hypertension, comorbid vascular conditions (diabetes mellitus and hyperlipidemia), and classes of anti-hypertensive medications using odds ratios and 95% confidence intervals. There were significant associations seen between PSP and hypertension (OR: 1.569; 95% CI 1.129–2.181; p-value = 0.007), education level (OR: 0.733; 95% CI 0.637–0.843; p-value<0.001) and beta-blocker use (OR: 2.000; 95% CI 1.053–3.799; p-value = 0.034). However, in the multi-variate analysis hypertension (OR: 1.492; 95% CI 1.045–2.129; p-value = 0.027) and education level (OR: 0.730; 95% CI 0.633–0.841; p-value<0.001) were the only significant associations. These results suggest that there is a modest, yet significant association between hypertension and PSP. Further studies will be needed to better understand the pathophysiological basis for this finding. •The association between hypertension and PSP is controversial in prior studies.•We found a significant positive association between previous hypertension and PSP in a large, multi-center, case-control study.•Further studies are needed to understand the relation between hypertension and PSP.