Details

Autor(en) / Beteiligte

• Potts, Bradley A
• Degoski, Danielle J
• Brooks, Jillene M
• Peterson, Andrew C
• Nelson, Dwight E
• Brink, Thaddeus S
• Fraser, Matthew O

Titel

Timing of sacral neurostimulation is important for increasing bladder capacity in the anesthetized rat

Ist Teil von

• American journal of physiology. Renal physiology, 2019-11, Vol.317 (5), p.F1183-F1188

Ort / Verlag

United States: American Physiological Society

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• We assessed the effects of limited application of sacral neurostimulation (SNS) during bladder filling on bladder capacity using our previously published SNS model in rats. Female Sprague-Dawley rats ( = 24) were urethane anesthetized (1.2 g/kg sc) and implanted with jugular venous and transvesical bladder catheters. L6/S1 nerve trunks were isolated bilaterally, and two electrodes were placed on each exposed nerve. True bladder capacity (TBC) was determined using stable single-fill cystometrograms. In the first series of experiments, SNS was applied at the onset of bladder filling for 25%, 50%, 75%, and 100% of the previous control filling cycle duration ( = 10). In the second series of experiments, SNS was applied during the first, second, third, and fourth 25% and the first and second 50% of the control fill. In the first series, a significant increase in TBC was observed only when SNS was applied for 75% or 100% of the control fill duration (30% and 35%, respectively, < 0.05). In the second series, significant increases in TBC only occurred during the fourth 25% period and second 50% period (32% and 43%, respectively, < 0.001). Results from the second series also revealed an increase in subsequent single-fill bladder capacities (TBC) only when SNS was applied during the second 50% of the prior fill cycle. These data indicate that the application of SNS during the final 50% of the bladder fill cycle is necessary and sufficient for increasing bladder capacity.