Details

Autor(en) / Beteiligte

• Santos García, D.
• Suárez Castro, E.
• Borrué, C.
• Solano Vila, B.
• Cots Foraster, A.
• Álvarez Sauco, M.
• Rodríguez Pérez, A.B.
• Vela, L.
• Macías, Y.
• Escalante, S.
• Cubo, E.
• Casas, E.
• Arnaiz, S.
• Carrillo Padilla, F.
• Pueyo Morlans, M.
• Mir, P.
• Martinez-Martin, P.
• Almeria, M.
• Alonso Cánovas, A.
• Alonso-Frech, F.
• Arribas, S.
• Ascunde Vidondo, A.
• Ávila, M.A.
• Bernardo Lambrich, N.
• Bejr-Kasem, H.
• Blázquez Estrada, M.
• Botí, M.
• Cabello González, C.
• Cabo López, I.
• Caballol, N.
• Cámara Lorenzo, A.
• Carrillo, F.
• Catalán, M.J.
• Clavero, P.
• Crespo Cuevas, A.
• de Fábregues-Boixar, O.
• Díez-Fairen, M.
• Estelrich Peyret, E.
• Fernández Guillán, N.
• Gámez, P.
• Gallego, M.
• García Moreno, J.M.
• Gastón, I.
• Gómez Garre, M.P.
• González Aloy, J.
• González-Aramburu, I.
• González García, B.
• González Palmás, M.J.
• González Toledo, G.R.
• Golpe Díaz, A.
• Grau Solá, M.
• Guardia, G.
• Hernández-Vara, J.
• Horta Barba, A.
• Infante, J.
• Kulisevsky, J.
• Kurtis, M.
• Labrador, M.A.
• Lacruz, F.
• Lage Castro, M.
• López Ariztegui, N.
• López Manzanares, L.
• López Seoane, B.
• Martí Andres, G.
• Martí, M.J.
• Martínez-Castrillo, J.C.
• McAfee, D.
• Menéndez González, M.
• Méndez del Barrio, C.
• Miranda Santiago, J.
• Morales Casado, M.I.
• Moreno Diéguez, A.
• Nogueira, V.
• Novo Amado, A.
• Novo Ponte, S.
• Ordás, C.
• Pagonabarraga, J.
• Pareés, I.
• Pérez Fuertes, A.
• Planellas, Ll
• Pol Fuster, J.
• Prats, M.A.
• Prieto Jurczynska, C.
• Puente, V.
• Redondo Rafales, N.
• Rodríguez Méndez, L.
• Roldán, F.
• Ruíz Martínez, J.
• Sánchez Alonso, P.
• Sánchez-Carpintero, M.
• Sánchez Díez, G.
• Sánchez Rodríguez, A.
• Santacruz, P.
• Segundo Rodríguez, J.C.
• Seijo, M.
• Tartari, J.P.
• Vázquez Gómez, R.
• Villanueva, C.
• Vives, B.
• Villar, M.D.

Titel

Non-motor symptoms burden, mood, and gait problems are the most significant factors contributing to a poor quality of life in non-demented Parkinson's disease patients: Results from the COPPADIS Study Cohort

Ist Teil von

• Parkinsonism & related disorders, 2019-09, Vol.66, p.151-157

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2019

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• To identify factors related to a poor health-related and global quality of life (QoL) in a cohort of non-demented Parkinson's disease (PD) patients and compare to a control group. The data correspond to the baseline evaluation of the COPPADIS-2015 Study, an observational, 5-year follow-up, multicenter, evaluation study. Three instruments were used to assess QoL: (1) the 39-item Parkinson's disease Questionnaire (PDQ-39), (2) a subjective rating of global QoL (PQ-10), and (3) the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Multiple linear regression methods were used to evaluate the direct impact of different variables on these QoL measures. QoL was worse in PD patients (n = 692; 62.6 ± 8.9 years old, 60.3% males) than controls (n = 206; 61 ± 8.3 years old, 49.5% males): PDQ-39, 17.1 ± 13.5 vs 4.4 ± 6.3 (p < 0.0001); PQ-10, 7.3 ± 1.6 vs 8.1 ± 1.2 (p < 0.0001); EUROHIS-QOL8, 3.8 ± 0.6 vs 4.2 ± 0.5 (p < 0.0001). A high correlation was observed between PDQ-39 and Non-Motor Symptoms Scale (NMSS) (r = 0.72; p < 0.0001), and PDQ-39 and Beck Depression Inventory-II (BDI-II) (r = 0.65; p < 0.0001). For health-related QoL (PDQ-39), non-motor symptoms burden (NMSS), mood (BDI-II), and gait problems (Freezing Of Gait Questionnaire [FOGQ]) provided the highest contribution to the model (β = 0.32, 0.28, and 0.27, respectively; p < 0.0001); whereas mood and gait problems contributed the most to global QoL (PQ-10, β = -0.46 and −0.21, respectively; EUROHIS-QOL8, β = -0.44 and −0.23, respectively). QoL is worse in PD patients than in controls. Mood, non-motor symptoms burden, and gait problems seem to be the most relevant factors affecting health-related and global perceived QoL in non-demented PD patients. •Non-motor symptoms (NMS) are frequent in Parkinson's disease (PD) patients during the first steps of the disease.•Health-related and global perceived quality of life (QoL) are worse in PD patients than controls.•Strong correlation was observed between PQ-10 and EUROHIS-QOL8, both scales to provide global QoL.•NMS burden, mood, and gait problems are the most significant factors contributing to a worse QoL.•In practice, it is necessary to ask about NMS, mood, and gait problems in PD patients during their first years of evolution.