Details

Autor(en) / Beteiligte

• Yang, Guangze
• Liu, Yun
• Wang, Haofei
• Wilson, Russell
• Hui, Yue
• Yu, Lei
• Wibowo, David
• Zhang, Cheng
• Whittaker, Andrew K.
• Middelberg, Anton P. J.
• Zhao, Chun‐Xia

Titel

Bioinspired Core–Shell Nanoparticles for Hydrophobic Drug Delivery

Ist Teil von

• Angewandte Chemie International Edition, 2019-10, Vol.58 (40), p.14357-14364

Auflage

International ed. in English

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A large range of nanoparticles have been developed to encapsulate hydrophobic drugs. However, drug loading is usually less than 10 % or even 1 %. Now, core–shell nanoparticles are fabricated having exceptionally high drug loading up to 65 % (drug weight/the total weight of drug‐loaded nanoparticles) and high encapsulation efficiencies (>99 %) based on modular biomolecule templating. Bifunctional amphiphilic peptides are designed to not only stabilize hydrophobic drug nanoparticles but also induce biosilicification at the nanodrug particle surface thus forming drug‐core silica–shell nanocomposites. This platform technology is highly versatile for encapsulating various hydrophobic cargos. Furthermore, the high drug loading nanoparticles lead to better in vitro cytotoxic effects and in vivo suppression of tumor growth, highlighting the significance of using high drug‐loading nanoparticles. Difunctional amphiphilic peptides were designed to not only stabilize hydrophobic drug nanoparticles but also induce biosilicification at the drug particle surface to maintain the long‐term stability of the nano‐drug. The drug‐core silica–shell nanocomposites have exceptionally high drug loading (up to 65 % w/w) and encapsulation efficiencies (>99 %).