Details

Autor(en) / Beteiligte

• Santos, Camilla N O
• Ribeiro, Danielle R
• Cardoso Alves, Juliana
• Cazzaniga, Rodrigo A
• Magalhães, Lucas S
• de Souza, Mércia S F
• Fonseca, Adriana B L
• Bispo, Ana J B
• Porto, Roseane L S
• Santos, Cliomar Alves dos
• da Silva, Ângela M
• Teixeira, Mauro M
• de Almeida, Roque P
• de Jesus, Amélia R

Titel

Association Between Zika Virus Microcephaly in Newborns With the rs3775291 Variant in Toll-Like Receptor 3 and rs1799964 Variant at Tumor Necrosis Factor-α Gene

Ist Teil von

• The Journal of infectious diseases, 2019-10, Vol.220 (11), p.1797-1801

Ort / Verlag

US: Oxford University Press

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Congenital Zika syndrome (CZS) is a cluster of malformation, and the mechanisms that lead it are still unclear. Using hypothesis-driven candidate genes and their function in viral infections, single-nucleotide polymorphisms (SNPs) were genotyped by quantitative polymerase chain reaction in a sample population from Sergipe State, Brazil. This study shows that rs3775291 SNP at Toll-like receptor 3, which triggers type I interferon antiviral responses in mothers infected by Zika virus during pregnancy, is associated with CZS occurrence (odds ratio [OR], 2.19; 95% confidence interval [CI], 1.158–4.148). Moreover, rs1799964 SNP at tumor necrosis factor-α gene in CZS babies is associated with severe microcephaly (OR, 2.63; 95% CI, 1.13–6.21).