Details

Autor(en) / Beteiligte

• Kiselevskii, M. V.
• Anisimova, N. Yu
• Sitdikova, S. M.
• Donenko, F. V.
• Popilyuk, S. F.
• L’vov, V. L.
• Kalyuzhin, O. V.

Titel

A Combination of Muramylpeptides from Gram-Negative Bacteria Corrects Hematological and Immunological Disorders Induced by Cyclophosphamide

Ist Teil von

• Bulletin of experimental biology and medicine, 2019-07, Vol.167 (3), p.371-374

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• We have studied the effect of a combination of three natural muramylpeptides containing a meso -diaminopimelic acid residue (polyramyl) on the subpopulations of circulating T cells, spleen morphology, and leukocyte level in the blood of C57Bl/6 mice with cyclophosphamideinduced immunosuppression. Intraperitoneal injections of cyclophosphamide in a dose of 100 mg/kg on days 1, 3, 5, and 7 of the experiment reduced leukocyte count and the relative number of CD4 + T cells in the blood, and also depleted the cellular composition of splenic white pulp on day 10. Subcutaneous injections of polyramyl in a dose of 200 μg/mouse on days 8 and 9 practically completely restored blood leukocytes count and morphology of the splenic white pulp. Moreover, administration of polyramyl induced marked tendency to increase in the relative number of CD4 + T cells and CD4/CD8 ratio in mice with cyclophosphamideinduced immunosuppression.