Clinical lung cancer, 2019-11, Vol.20 (6), p.e601-e608
2019
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- Autor(en) / Beteiligte
- Titel
- Prognostic Significance of Liver Metastasis in Durvalumab-Treated Lung Cancer Patients
- Ist Teil von
- Clinical lung cancer, 2019-11, Vol.20 (6), p.e601-e608
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2019
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Two clinical studies (Study 1108 and ATLANTIC) were analyzed to evaluate the prognostic value of baseline liver metastases (LMs) in advanced/metastatic non–small-cell lung cancer patients treated with durvalumab 10 mg/kg every 2 weeks. A multivariate Cox proportional hazards analysis was conducted; covariates included performance status, tumor stage, histology, sex, age, smoking status, and programmed cell death ligand 1 (PD-L1) status. In all, 569 patients were included. LMs were present in 31.6% (96/304) of Study 1108 patients and 17.9% (47/263) of ATLANTIC patients. Median overall survival (OS) was shorter in patients with LMs than in those without in both studies. In both studies, LMs were an independent negative prognostic factor for OS and progression-free survival. Objective response rates were also significantly lower. PD-L1 independently predicted benefit across all patients. Liver metastases were associated with worse outcomes irrespective of PD-L1 status, but PD-L1 status predicted benefit from durvalumab irrespective of LMs. The prognostic value of baseline liver metastases (LMs) was evaluated in 569 patients with advanced/metastatic non–small-cell lung cancer receiving the programmed cell death ligand 1 (PD-L1) inhibitor durvalumab. LMs were an independent negative prognostic factor for survival and were associated with significantly lower objective response rates. However, PD-L1 as an independent factor predicted benefit from durvalumab.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1525-7304eISSN: 1938-0690DOI: 10.1016/j.cllc.2019.06.020Titel-ID: cdi_proquest_miscellaneous_2261970392
- Format
- –
- Schlagworte
- Aged, Antibodies, Monoclonal - therapeutic use, Antineoplastic Agents, Immunological - therapeutic use, B7-H1 Antigen - antagonists & inhibitors, B7-H1 Antigen - metabolism, Carcinoma, Non-Small-Cell Lung - diagnosis, Carcinoma, Non-Small-Cell Lung - drug therapy, Carcinoma, Non-Small-Cell Lung - mortality, Carcinoma, Non-Small-Cell Lung - secondary, Female, Humans, Immunotherapy, Immunotherapy - methods, Liver Neoplasms - diagnosis, Liver Neoplasms - drug therapy, Liver Neoplasms - mortality, Liver Neoplasms - secondary, Lung Neoplasms - diagnosis, Lung Neoplasms - drug therapy, Lung Neoplasms - mortality, Lung Neoplasms - pathology, Male, Neoplasm Metastasis, Neoplasm Staging, Patient Selection, PD-L1, Prognosis, Response rate, Survival, Survival Analysis, Treatment Outcome