Physiological reviews, 2019-10, Vol.99 (4), p.1655-1699
2019
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Details
- Autor(en) / Beteiligte
- Titel
- Cell Adhesion by Integrins
- Ist Teil von
- Physiological reviews, 2019-10, Vol.99 (4), p.1655-1699
- Ort / Verlag
- United States: American Physiological Society
- Erscheinungsjahr
- 2019
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Integrins are heterodimeric cell surface receptors ensuring the mechanical connection between cells and the extracellular matrix. In addition to the anchorage of cells to the extracellular matrix, these receptors have critical functions in intracellular signaling, but are also taking center stage in many physiological and pathological conditions. In this review, we provide some historical, structural, and physiological notes so that the diverse functions of these receptors can be appreciated and put into the context of the emerging field of mechanobiology. We propose that the exciting journey of the exploration of these receptors will continue for at least another new generation of researchers.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0031-9333eISSN: 1522-1210DOI: 10.1152/physrev.00036.2018Titel-ID: cdi_proquest_miscellaneous_2259356316
- Format
- –
- Schlagworte
- Adaptor Proteins, Signal Transducing - metabolism, Animals, Cell Adhesion, Cell adhesion & migration, Cell Membrane - metabolism, Cell Proliferation, Cell surface, Extracellular matrix, Extracellular Matrix - metabolism, Humans, Integrins, Integrins - chemistry, Integrins - metabolism, Intracellular Signaling Peptides and Proteins - metabolism, Intracellular signalling, Mechanotransduction, Cellular, Models, Molecular, Phosphoproteins - metabolism, Physiology, Protein Conformation, Structure-Activity Relationship, Trans-Activators, Transcription Factors