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Clinical practice guidelines (CPGs) are used to support clinicians and patients in diagnostic and treatment decision-making. Along with patients' preferences and values, and clinicians' experience and judgment, practice guidelines are a critical component to ensure patients are getting the best care based on the most updated research findings. Most CPGs are based on systematic reviews of the treatment literature. Although most reviews are now restricted to randomized controlled trials, others may consider nonrandomized effectiveness trials. Despite a reliance on similar procedures and data, methodological decisions and the interpretation of the evidence by the guideline development panel can result in different recommendations. In this article, we will describe key methodological points for 5 recently released CPGs on the treatment of posttraumatic stress disorder in adults and highlight some of the differences in both the process and the subsequent recommendations.
Clinical Impact Statement
Question: What are the primary posttraumatic stress disorder treatment recommendations across the various posttraumatic stress disorder clinical practice guidelines? Findings: All of the guidelines gave the highest overall recommendations to trauma-focused psychotherapies (usually including eye movement desensitization and reprocessing), and all agreed that selective serotonin reuptake inhibitors (either specific ones or the whole class) were the most effective medications. Meaning: There is general consistency across the posttraumatic stress disorder clinical practice guidelines. Next Steps: Clinical practice guideline recommendations need to be disseminated to clinicians and, along with patient preferences, used to guide treatment decision-making.