Details

Autor(en) / Beteiligte

• Rhodes, Johanna
• Fisher, Matthew C

Titel

Global epidemiology of emerging Candida auris

Ist Teil von

• Current opinion in microbiology, 2019-12, Vol.52, p.84-89

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• •Candida auris is a newly identified and globally emerging fungal infection.•C. auris shows extensive innate and acquired resistance to antifungal drugs.•The fungus is intrinsically resistant to widely used hospital disinfectants leading to high rates of nosocomial transmission.•Research into virulence and treatment of C. auris in susceptible patients is urgently needed. The discovery in 2009 of a new species of yeast, Candida auris, heralded the arrival of a novel emerging human infectious disease. This review highlights the unique characteristics of C. auris that have lled to it being of public health concern worldwide, namely public health concern, namely its global emergence, its ability to cause nosocomial outbreaks in healthcare settings, its innate and emerging resistance to multiple antifungal drugs and its resilience in the face of hygiene and infection control measures. Genomic epidemiology has identified four emergences of C. auris marked by four clades of the pathogen. These clades of C. auris are genetically dissimilar and are associated with differential resistance to antifungal drugs, suggesting that they will continue to phenotypically diverge into the future. The global emergence of C. auris testifies to the unmapped nature of Kingdom Fungi, and represents a new nosocomial threat that will require enhanced infection control across diverse healthcare and community settings.