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TASK Channels Pharmacology: New Challenges in Drug Design
Ist Teil von
Journal of medicinal chemistry, 2019-11, Vol.62 (22), p.10044-10058
Ort / Verlag
United States: American Chemical Society
Erscheinungsjahr
2019
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Rational drug design targeting ion channels is an exciting and always evolving research field. New medicinal chemistry strategies are being implemented to explore the wild chemical space and unravel the molecular basis of the ion channels modulators binding mechanisms. TASK channels belong to the two-pore domain potassium channel family and are modulated by extracellular acidosis. They are extensively distributed along the cardiovascular and central nervous systems, and their expression is up- and downregulated in different cancer types, which makes them an attractive therapeutic target. However, TASK channels remain unexplored, and drugs designed to target these channels are poorly selective. Here, we review TASK channels properties and their known blockers and activators, considering the new challenges in ion channels drug design and focusing on the implementation of computational methodologies in the drug discovery process.
Sprache
Englisch
Identifikatoren
ISSN: 0022-2623
eISSN: 1520-4804
DOI: 10.1021/acs.jmedchem.9b00248
Titel-ID: cdi_proquest_miscellaneous_2251114237
Format
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