Details

Autor(en) / Beteiligte

• Wang, Xia
• Yang, Qiu-Xia
• Long, Cheng-Yu
• Tan, Yan
• Qu, Yi-Xin
• Su, Min-Hui
• Huang, Si-Jie
• Tan, Weihong
• Wang, Xue-Qiang

Titel

Anticancer-Active N‑Heteroaryl Amines Syntheses: Nucleophilic Amination of N‑Heteroaryl Alkyl Ethers with Amines

Ist Teil von

• Organic letters, 2019-07, Vol.21 (13), p.5111-5115

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A mild amination protocol of N-heteroaryl alkyl ethers with various amines is described. This transformation is achieved by utilizing simple and readily available base as promoter via C–O bond cleavage, offering a new amination strategy to access several anticancer-active compounds. This work is highlighted by the excellent functional group compatibility, scalability, wide substrate scope, and easy derivatization of a variety of drugs.