Details

Autor(en) / Beteiligte

• Cao, Jingming
• Thor, Waygen
• Yang, Shenkun
• Zhang, Mengxun
• Bao, Wenli
• Zhu, Lizhi
• Yang, Wei
• Cheng, Yuen-Kit
• Lee, Chi-Sing

Titel

Synthesis of the Tricyclic Picrotoxane Motif by an Oxidative Cascade Cyclization

Ist Teil von

• Organic letters, 2019-06, Vol.21 (12), p.4896-4899

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• An oxidative cascade cyclization of β-keto esters has been developed for the construction of the tricyclic picrotoxane motif in a single step, and DFT calculations suggested a possible cationic cyclization mechanism. This cascade cyclization can be operated on a 20 g scale to obtain a 77% total yield of the tricyclic products, which in turn can be converted to versatile intermediates for further elaboration to picrotoxanes and their structurally related compounds.