Bulletin of experimental biology and medicine, 2019-06, Vol.167 (2), p.279-283
2019
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Details
- Autor(en) / Beteiligte
- Titel
- Analysis of the Action of Quaternized Chitosans with Different Molecular Weight on Anticoagulant Activity of Heparins In Vitro
- Ist Teil von
- Bulletin of experimental biology and medicine, 2019-06, Vol.167 (2), p.279-283
- Ort / Verlag
- New York: Springer US
- Erscheinungsjahr
- 2019
- Quelle
- SpringerLink
- Beschreibungen/Notizen
- Quaternized derivatives of chitosan with a substitution degree of 85-98% (highly substituted) synthesized from chitosans with a molecular weight of 5, 10, 20 kDa, with a degree of deacetylation of 89-98%, and the code numbers of QChit 5, QChit 10, QChit 20, respectively, completely neutralize antithrombin activity of unfractionated heparin and partially neutralize aXa activity of low-molecular-weight heparin (clexane), similar to protamine sulfate. The advantages of QChit 5 and QChit 10 over QChit 20 and protamine sulphate are the follows: the effect is achieved at lower concentrations and in greater concentration range; they do not promote platelet aggregation; in a concentration of 0.0072 mg/ml they do not destroy the erythrocyte membranes.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0007-4888eISSN: 1573-8221DOI: 10.1007/s10517-019-04509-wTitel-ID: cdi_proquest_miscellaneous_2248381155
- Format
- –
- Schlagworte
- Anticoagulants, Anticoagulants (Medicine), Anticoagulants - chemistry, Anticoagulants - pharmacology, Antithrombin, Biomedical and Life Sciences, Biomedicine, Blood Coagulation Tests, Cell Biology, Chitosan, Chitosan - chemistry, Deacetylation, Hemolysis - drug effects, Heparin, Heparin - chemistry, Heparin - pharmacology, Humans, Internal Medicine, Laboratory Medicine, Molecular weight, Pathology, Platelet aggregation, Platelet Aggregation - drug effects, Protamine sulfate, Sulfates