Bulletin of experimental biology and medicine, 2019-06, Vol.167 (2), p.259-262
2019
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Characteristics of Artificial Immunogens Containing Peptide Mimotopes of HIV-1 Epitopes Recognized by Monoclonal Antibodies 2F5 and 2G12
- Ist Teil von
- Bulletin of experimental biology and medicine, 2019-06, Vol.167 (2), p.259-262
- Ort / Verlag
- New York: Springer US
- Erscheinungsjahr
- 2019
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The paper describes construction of TBI-based recombinant proteins TBI-2F5 and TBI-2G12 that contain peptide mimotopes of HIV-1 epitopes recognized by broadly neutralizing antibodies 2F5 and 2G12, respectively. The capacity of the immunogens to induce neutralizing antibodies was evaluated. The sera of BALB/c mice immunized with recombinant proteins TBI, TBI-2F5, and TBI-2G12 neutralized HIV-1 env- pseudoviruses. Moreover, pooled serum from mice immunized with TBI-2F5 and TBI-2G12 neutralized env- pseudoviruses of HIV-1 subtype B more effectively than individual sera.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0007-4888eISSN: 1573-8221DOI: 10.1007/s10517-019-04504-1Titel-ID: cdi_proquest_miscellaneous_2248378623
- Format
- –
- Schlagworte
- AIDS vaccines, Animals, Antibodies, Monoclonal - immunology, Antibodies, Neutralizing - immunology, Antigenic determinants, Biomedical and Life Sciences, Biomedicine, Broadly Neutralizing Antibodies - immunology, Cell Biology, Cell Surface Display Techniques, Epitopes, Epitopes - immunology, Health aspects, HIV, HIV (Viruses), HIV Antibodies - immunology, HIV infection, HIV-1 - immunology, Human immunodeficiency virus, Immunoglobulins, Internal Medicine, Laboratory Medicine, Male, Mice, Mice, Inbred BALB C, Monoclonal antibodies, Pathology, Peptides, Recombinant proteins, Tissue engineering