Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Ergebnis 16 von 31

Details

Autor(en) / Beteiligte
Titel
Effects of oral supplementation in the management of oral mucositis in cancer patients: A meta‐analysis of randomized clinical trials
Ist Teil von
  • Journal of oral pathology & medicine, 2020-02, Vol.49 (2), p.117-125
Ort / Verlag
Denmark: Wiley Subscription Services, Inc
Erscheinungsjahr
2020
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
  • Purpose To evaluate the effects of oral supplementation on the management of oral mucositis in patients with cancer undergoing chemo and/or radiation therapy. Method This is a systematic review and meta‐analysis. The search was performed at 6 databases, and in the gray literature. Methodology of included studies was evaluated by the Cochrane Collaboration Risk of Bias Tool, and evidence quality was assessed by GRADE instrument. Results Twelve randomized clinical trials were included in this review. The oral supplementation used was an oral elemental diet with amino acids and minerals (elental), glutamine, and zinc. The majority of the studies included in this review showed benefits in delaying the occurrence of OM by using glutamine and zinc, and in reducing the severity of OM with glutamine, zinc, and elental in patients receiving chemoradiotherapy. The meta‐analysis showed that the risk of oral mucositis in the zinc group was slightly lower than in the control (RR: 0.71, 95% CI: 0.53‐0.96, P = 0.02, n = 982) while the glutamine group presented the same risk as the control (RR: 0.91, 95% CI: 0.78‐1.05, P = 0.19, n = 314). The evidence quality suggested low confidence for zinc and glutamine studies in the estimated effect from the outcomes assessed. Conclusions Zinc is a promising strategy in the management of oral mucositis since it delayed the occurrence and reduced its severity. Glutamine and Elental, on the other hand, had no strong evidence in the prevention and/or treatment of oral mucositis in patients with cancer.
Sprache
Englisch
Identifikatoren
ISSN: 0904-2512
eISSN: 1600-0714
DOI: 10.1111/jop.12901
Titel-ID: cdi_proquest_miscellaneous_2246907052

Weiterführende Literatur

Empfehlungen zum selben Thema automatisch vorgeschlagen von bX