Details

Autor(en) / Beteiligte

• Sonni, Ida
• Minamimoto, Ryogo
• Baratto, Lucia
• Gambhir, Sanjiv S.
• Loening, Andreas M.
• Vasanawala, Shreyas S.
• Iagaru, Andrei

Titel

Simultaneous PET/MRI in the Evaluation of Breast and Prostate Cancer Using Combined Na[18F] F and [18F]FDG: a Focus on Skeletal Lesions

Ist Teil von

• Molecular imaging and biology, 2020-04, Vol.22 (2), p.397-406

Ort / Verlag

Cham: Springer International Publishing

Erscheinungsjahr

2020

Link zum Volltext

Quelle

SpringerLink (Online service)

Beschreibungen/Notizen

• Purpose The purpose of this study is to prospectively evaluate the performance of sodium 18 F]fluoride (Na[ 18 F]F)/2-deoxy-2-[ 18 F]fluoro-D-glucose ([ 18 F]FDG) simultaneous time-of-flight enabled positron emission tomography (PET)/magnetic resonance imaging (MRI) for the detection of skeletal metastases in selected patients with advanced breast and prostate cancers. Procedure The institutional review board approved this HIPAA-compliant protocol. Written informed consent was obtained from each patient. A total of 74 patients (23 women and 51 men with breast and prostate cancer, respectively) referred for standard-of-care whole-body bone scintigraphy (WBBS) were enrolled in this prospective study. All patients underwent a [ 99m Tc]methyldiphosphonate ([ 99m Tc]MDP) WBBS followed by Na[ 18 F]F/[ 18 F]FDG PET/MRI. Lesions detected by each imaging modality were tabulated and a lesion-based and patient-based analysis was conducted. Results On a patient-based analysis, [ 99m Tc]MDP WBBS identified skeletal lesions in 37 patients and PET/MRI in 45 patients. On a lesion-based analysis, WBBS identified a total of 81 skeletal lesions, whereas PET/MRI identified 140 lesions. Additionally, PET/MRI showed extra-skeletal lesions in 19 patients, including lymph nodes (16), prostate (4) lung (3), and liver (2) lesions. Conclusions The ability of Na[ 18 F]F/[ 18 F]FDG PET/MRI to identify more skeletal lesions than 99m Tc-MDP WBBS and to additionally identify extra-skeletal disease may be beneficial for patient care and represent an alternative to the single modalities performed separately. Na[ 18 F]F/[ 18 F]FDG PET/MRI is a promising approach for evaluation of skeletal and extra-skeletal lesions in a selected population of breast and prostate cancer patients.