Details

Autor(en) / Beteiligte

• Humblin, Etienne
• Kamphorst, Alice O.

Titel

CXCR3-CXCL9: It’s All in the Tumor

Ist Teil von

• Immunity (Cambridge, Mass.), 2019-06, Vol.50 (6), p.1347-1349

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2019

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• In this issue of Immunity, Chow et al. (2019) show that the CXCR3-CXCL9 axis is required for reinvigoration of intratumoral CD8+ T cell responses in response to PD-1 blockade and demonstrate that local guidance to dendritic cells, rather than recruitment of T cells into the tumor, underlies the importance of this chemokine axis. In this issue of Immunity, Chow et al. (2019) show that the CXCR3-CXCL9 axis is required for reinvigoration of intratumoral CD8+ T cell responses in response to PD-1 blockade and demonstrate that local guidance to dendritic cells, rather than recruitment of T cells into the tumor, underlies the importance of this chemokine axis.