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Nature reviews. Nephrology, 2019-09, Vol.15 (9), p.559-575
2019
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Autor(en) / Beteiligte
Titel
Extracellular DNA traps in inflammation, injury and healing
Ist Teil von
  • Nature reviews. Nephrology, 2019-09, Vol.15 (9), p.559-575
Ort / Verlag
England
Erscheinungsjahr
2019
Quelle
MEDLINE
Beschreibungen/Notizen
  • Following strong activation signals, several types of immune cells reportedly release chromatin and granular proteins into the extracellular space, forming DNA traps. This process is especially prominent in neutrophils but also occurs in other innate immune cells such as macrophages, eosinophils, basophils and mast cells. Initial reports demonstrated that extracellular traps belong to the bactericidal and anti-fungal armamentarium of leukocytes, but subsequent studies also linked trap formation to a variety of human diseases. These pathological roles of extracellular DNA traps are now the focus of intensive biomedical research. The type of pathology associated with the release of extracellular DNA traps is mainly determined by the site of trap formation and the way in which these traps are further processed. Targeting the formation of aberrant extracellular DNA traps or promoting their efficient clearance are attractive goals for future therapeutic interventions, but the manifold actions of extracellular DNA traps complicate these approaches.
Sprache
Englisch
Identifikatoren
ISSN: 1759-5061
eISSN: 1759-507X
DOI: 10.1038/s41581-019-0163-2
Titel-ID: cdi_crossref_primary_10_1038_s41581_019_0163_2

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