Details

Autor(en) / Beteiligte

• Ishikawa, Asano
• Kabeya, Naoki
• Ikeya, Koki
• Kakioka, Ryo
• Cech, Jennifer N
• Osada, Naoki
• Leal, Miguel C
• Inoue, Jun
• Kume, Manabu
• Toyoda, Atsushi
• Tezuka, Ayumi
• Nagano, Atsushi J
• Yamasaki, Yo Y
• Suzuki, Yuto
• Kokita, Tomoyuki
• Takahashi, Hiroshi
• Lucek, Kay
• Marques, David
• Takehana, Yusuke
• Naruse, Kiyoshi
• Mori, Seiichi
• Monroig, Oscar
• Ladd, Nemiah
• Schubert, Carsten J
• Matthews, Blake
• Peichel, Catherine L
• Seehausen, Ole
• Yoshizaki, Goro
• Kitano, Jun

Titel

A key metabolic gene for recurrent freshwater colonization and radiation in fishes

Ist Teil von

• Science (American Association for the Advancement of Science), 2019-05, Vol.364 (6443), p.886-889

Ort / Verlag

United States: The American Association for the Advancement of Science

Erscheinungsjahr

2019

Quelle

American Association for the Advancement of Science

Beschreibungen/Notizen

• Colonization of new ecological niches has triggered large adaptive radiations. Although some lineages have made use of such opportunities, not all do so. The factors causing this variation among lineages are largely unknown. Here, we show that deficiency in docosahexaenoic acid (DHA), an essential ω-3 fatty acid, can constrain freshwater colonization by marine fishes. Our genomic analyses revealed multiple independent duplications of the fatty acid desaturase gene in stickleback lineages that subsequently colonized and radiated in freshwater habitats, but not in close relatives that failed to colonize. Transgenic manipulation of in marine stickleback increased their ability to synthesize DHA and survive on DHA-deficient diets. Multiple freshwater ray-finned fishes also show a convergent increase in copies, indicating its key role in freshwater colonization.