Details

Autor(en) / Beteiligte

• Ling, Fei
• Hou, Huacui
• Chen, Jiachen
• Nian, Sanfei
• Yi, Xiao
• Wang, Ze
• Song, Dingguo
• Zhong, Weihui

Titel

Highly Enantioselective Synthesis of Chiral Benzhydrols via Manganese Catalyzed Asymmetric Hydrogenation of Unsymmetrical Benzophenones Using an Imidazole-Based Chiral PNN Tridentate Ligand

Ist Teil von

• Organic letters, 2019-06, Vol.21 (11), p.3937-3941

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2019

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A series of Mn­(I) catalysts containing imidazole-based chiral PNN tridentate ligands with controllable “side arm” groups have been established, enabling the asymmetrical hydrogenation of unsymmetrical benzophenones with outstanding activity (up to 13 000 TON) and excellent enantioselectivity (up to >99% ee). This protocol uses K2CO3 as an industrially desirable base and features a wide substrate scope and functional group tolerance. Moreover, the imine group in the catalyst is crucial for accessing high activities and good enantioselectivities.