Details

Autor(en) / Beteiligte

• Bisbal, Felipe
• Alarcón, Francisco
• Ferrero‐De‐Loma‐Osorio, Angel
• González‐Ferrer, Juan Jose
• Alonso‐Martín, Concepción
• Pachón, Marta
• Vallés, Ermengol
• Cabanas‐Grandío, Pilar
• Sanchez, Manuel
• Benito, Eva
• Sarrias, Axel
• Ruiz‐Granell, Ricardo
• Pérez‐Villacastín, Julián
• Viñolas, Xavier
• Arias, Miguel Angel
• Martí‐Almor, Julio
• García‐Campo, Enrique
• Fernández‐Lozano, Ignacio
• Villuendas, Roger
• Mont, Lluís

Titel

Diagnosis‐to‐ablation time in atrial fibrillation: A modifiable factor relevant to clinical outcome

Ist Teil von

• Journal of cardiovascular electrophysiology, 2019-09, Vol.30 (9), p.1483-1490

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Introduction Recurrences after atrial fibrillation (AF) ablation are still common. Among the reported clinical and imaging predictors of recurrences, diagnosis‐to‐ablation time (DAT) has been defined as a predictor of ablation outcome in single‐center studies. We aimed to validate DAT in a multicenter real‐life cohort. Methods This was a multicenter study including consecutive patients undergoing first paroxysmal and persistent AF ablation with radiofrequency or cryoballoon catheters during 2013. Cox proportional hazard regression models were performed to identify predictors of recurrence. Results In total, 309 patients were included across nine centers (71% men, 57 ± 10 years old, 46% with hypertension, and 66% with CHA2DS2‐VASc ≤ 1). Most patients had paroxysmal AF (67%) and underwent radiofrequency ablation (68%) with a median DAT of 51 (43) months. Patients with DAT ≤ 1 year (16.6%) were less likely to have repeat procedures (4% vs 18%; P = .017). The adjusted proportional hazards Cox model identified hypertension (P = .005), heart failure (P = .011), nonparoxysmal AF (P = .038), DAT > 1 year (P = .007), and LA diameter (P = .026) as independent predictors for AF recurrence. DAT > 1 year was the only modifiable factor independently associated with recurrence (HR 4.2 [95% CI, 1.5‐11.9]) Conclusion Diagnosis‐to‐ablation time is a modifiable factor independently associated with recurrent arrhythmia and repeat ablation after first AF ablation. An early intervention strategy during the first year from AF diagnosis might improve outcomes.