Details

Autor(en) / Beteiligte

• Wong, Vincent C.H.
• Maguire, Jonathon L.
• Dai, David W.H.
• Lebovic, Gerald
• O'Connor, Deborah L.
• Birken, Catherine S.
• Cohn, Ronald
• Lau, Eddy
• Salter, Michael
• Anderson, Laura N.
• Borkhoff, Cornelia M.
• Kowal, Christine
• Abdurrahman, Murtala
• Anderson, Kelly
• Baker, Jillian
• Barozzino, Tony
• Bergeron, Sylvie
• Bhagat, Dimple
• Bonifacio, Joey
• Bowry, Ashna
• Calpin, Caroline
• Campbell, Douglas
• Constantin, Evelyn
• Danayan, Karoon
• Das, Paul
• Derocher, Mary Beth
• Do, Anh
• Doukas, Kathleen
• Egger, Anne
• Freeman, Sloane
• Gazeley, Sharon
• Guiang, Charlie
• Ha, Dan
• Handford, Curtis
• Hanson, Laura
• Harrington, Leah
• Jansz, Gwen
• Kim, Florence
• Kwok, Bruce
• Lakhoo, Sheila
• Lam-Antoniades, Margarita
• Leduc, Denis
• Li, Alan
• Malach, Jessica
• Male, Roy
• Mascoll, Vashti
• Moodie, Rosemary
• Nader, Maya
• Nash, Katherine
• Pena, Kifi
• Perlmutar, Marty
• Persaud, Navindra
• Pinto, Andrew
• Porepa, Michelle
• Qi, Vikky
• Ramji, Noor
• Raza, Danyaal
• Rosenthal, Alana
• Rouleau, Katherine
• Ruderman, Caroline
• Saunderson, Janet
• Schiralli, Vanna
• Sgro, Michael
• Shuja, Hafiz
• Smiltnieks, Barbara
• Srikanthan, Cinntha
• Uddin, Fatima
• van den Heuvel, Meta
• Vaughan, Joanne
• Weisdorf, Thea
• Wijayasinghe, Sheila
• Yaremko, John
• Ying, Ethel
• Young, Elizabeth
• Zajdman, Michael
• Bazeghi, Farnaz
• Bouchard, Vincent
• Bustos, Marivic
• Dalwadi, Dharma
• Koroshegyi, Christine
• Malhi, Tarandeep
• Thadani, Sharon
• Thompson, Julia
• Thompson, Laurie
• Aglipay, Mary
• Bayoumi, Imaan
• Cost, Katherine
• Eny, Karen
• Omand, Jessica
• Vanderhout, Shelley
• Vanderloo, Leigh
• Allen, Christopher
• Pope, Karen
• Thorpe, Kevin
• Kandel, Rita
• Rodrigues, Michelle
• Vandenberghe, Hilde

Titel

A Positive Association Between Dietary Intake of Higher Cow's Milk-Fat Percentage and Non−High-Density Lipoprotein Cholesterol in Young Children

Ist Teil von

• The Journal of pediatrics, 2019-08, Vol.211, p.105-111.e2

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• To determine the association between cow's milk-fat and non−high-density lipoprotein (non-HDL) cholesterol, a marker of cardiovascular disease (CVD) risk in young children, and whether this association is mediated by the typical volume of cow's milk consumed. A longitudinal study in 2- to 8-year-old children (n = 2890) was conducted through The Applied Research Group for Kids (TARGet Kids!), a practice-based research network in Toronto, Canada. Generalized estimating equations were used to examine the relationship between parent-reported cow's milk-fat percentage intake and serum non-HDL cholesterol concentrations as well as having high non-HDL cholesterol (≥3.75 mmol/L [145 mg/dL]), adjusting for covariates including age, sex, body mass index z score, breastfeeding duration, mother's ethnicity, and parental history of CVD. Bootstrap resampling (10 000 repetitions) was used to assess whether typical volume consumed mediated the association between cow's milk-fat percentage and non-HDL cholesterol. In total, 156 (5.4%) had high non-HDL cholesterol. Each percent increase in cow's milk-fat was associated with a 0.035 mmol/L (1.35 mg/dL) (P < .001) and 0.024 mmol/L (0.92 mg/dL) (P = .01) increase in non-HDL cholesterol, unadjusted and adjusted for covariates respectively. Cow's milk-fat percentage was not associated with greater odds of having high non-HDL cholesterol. Volume of cow's milk partially mediated the association between cow's milk-fat percentage and non-HDL cholesterol, accounting for 28% of the relationship (P < .001). Consumption of higher-fat cow's milk was associated with a small increase in non-HDL cholesterol but not greater odds of having high non-HDL cholesterol. Further research is needed to assess this relationship with other CVD risk factors in young children. ClinicalTrials.gov: NCT01869530.