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Response to: A Phase III open-label, randomized, active controlled clinical study to assess safety, immunogenicity and lot-to-lot consistency of a bovine-human reassortant pentavalent rotavirus vaccine in Indian infants
Ist Teil von
Vaccine, 2019-05, Vol.37 (23), p.2990-2990
Ort / Verlag
Netherlands: Elsevier Ltd
Erscheinungsjahr
2019
Quelle
Access via ScienceDirect (Elsevier)
Beschreibungen/Notizen
[...]the measurement of immune responses of two vaccines that are conceptually different from each other in their antigenic composition require vaccine-specific assays. [...]using different blood sampling timing for each vaccine (four weeks after the last dose of active vaccination for Rotasiil versus eight weeks for Rotarix) is a methodological error in the immunogenicity evaluation. [...]the impact of post-vaccination blood sampling timepoint on antibody titers and subsequent seropositivity rates has been previously highlighted [3]. [...]information on timing of blood sampling for Rotarix is only provided in the last paragraph of the discussion.