The New England journal of medicine, 2019-08, Vol.381 (7), p.614-625
2019
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Details
- Autor(en) / Beteiligte
- Titel
- Eculizumab in Aquaporin-4–Positive Neuromyelitis Optica Spectrum Disorder
- Ist Teil von
- The New England journal of medicine, 2019-08, Vol.381 (7), p.614-625
- Ort / Verlag
- United States: Massachusetts Medical Society
- Erscheinungsjahr
- 2019
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Neuromyelitis optica spectrum disorder is a relapsing inflammatory disorder of the central nervous system. Two thirds of patients have antibodies against aquaporin-4, and CNS damage is complement dependent. The inhibitor of terminal complement C5 cleavage, eculizumab, reduced relapses of NMOSD.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-4793eISSN: 1533-4406DOI: 10.1056/NEJMoa1900866Titel-ID: cdi_proquest_miscellaneous_2229233856
- Format
- –
- Schlagworte
- Adult, Antibodies, Monoclonal, Humanized - adverse effects, Antibodies, Monoclonal, Humanized - therapeutic use, Aquaporin 4, Aquaporin 4 - immunology, Aquaporins, Autoantibodies - blood, Central nervous system, Complement C5 - antagonists & inhibitors, Complement Inactivating Agents - adverse effects, Complement Inactivating Agents - therapeutic use, Complement inhibitors, Complement system, Design, Disability Evaluation, Disease Progression, Double-Blind Method, Double-blind studies, Drug Therapy, Combination, Empyema, Female, Headache, Headache - chemically induced, Humans, Immunoglobulin G, Immunoglobulin G - blood, Immunoglobulins, Immunosuppressive agents, Immunosuppressive Agents - adverse effects, Immunosuppressive Agents - therapeutic use, Infections, Inflammatory diseases, Intravenous administration, Male, Medical laboratories, Monoclonal antibodies, Nervous system, Neuromyelitis, Neuromyelitis Optica - drug therapy, Neuromyelitis Optica - immunology, Pharmaceuticals, Physicians, Quality of Life, Regulatory approval, Respiratory tract diseases, Respiratory Tract Infections - etiology, Secondary Prevention, Spinal cord