Details

Autor(en) / Beteiligte

• Hu, Ming‐Jun
• Zhang, Chi
• Liang, Ling
• Wang, Sheng‐Ying
• Zheng, Xu‐Cai
• Zhang, Qian
• Jiang, Chun‐Xiao
• Zhong, Qi
• Huang, Fen

Titel

Fasting serum glucose, thyroid‐stimulating hormone, and thyroid hormones and risk of papillary thyroid cancer: A case‐control study

Ist Teil von

• Head & neck, 2019-07, Vol.41 (7), p.2277-2284

Ort / Verlag

Hoboken, USA: John Wiley & Sons, Inc

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Background This study was to investigate the association of fasting serum glucose (FSG), thyroid‐stimulating hormone (TSH), and thyroid hormones with papillary thyroid cancer (PTC). Methods A total of 649 participants were included in this case‐control study. The associations of FSG, TSH, free triiodothyronine (FT3) and free thyroxine (FT4) with PTC were estimated using an unconditional logistic regression. Results Compared with the lowest quintile of TSH levels, odds ratios (ORs) and 95% confidence intervals (CIs) for association between PTC risk and highest quintile of TSH levels were 1.67 (95% CI, 0.99‐2.83). However, this risk correlation was more significant in PTC cases with ≤1.0 cm tumor size (adjusted OR, 1.95; 95% CI, 1.08‐3.54; adjusted P‐trend, 0.05). The PTC risk was also inversely associated with the serum FT3 level in all participants (adjusted P‐trend, 0.001), but positively associated with the serum FT4 (adjusted P‐trend, 0.001) and FSG (adjusted P‐trend, 0.01) levels. Among the participants without diabetes, the individuals with high FSG levels and abnormal TSH concentration had an increased PTC risk (adjusted OR, 3.38; 95% CI, 1.78‐6.42). Conclusion The current study provides evidence for the association of FSG, TSH, and thyroid hormones (FT3 and FT4) with PTC risk. However, larger relative studies are needed.