Details

Autor(en) / Beteiligte

• Amoah, Samuel
• Mishina, Margarita
• Praphasiri, Prabda
• Cao, Weiping
• Kim, Jin Hyang
• Liepkalns, Justine S
• Guo, Zhu
• Carney, Paul J
• Chang, Jessie C
• Fernandez, Stefan
• Garg, Shikha
• Beacham, Lauren
• Holtz, Timothy H
• Curlin, Marcel E
• Dawood, Fatimah
• Olsen, Sonja J
• Gangappa, Shivaprakash
• Stevens, James
• Sambhara, Suryaprakash

Titel

Standard-Dose Intradermal Influenza Vaccine Elicits Cellular Immune Responses Similar to Those of Intramuscular Vaccine in Men With and Those Without HIV Infection

Ist Teil von

• The Journal of infectious diseases, 2019-07, Vol.220 (5), p.743-751

Ort / Verlag

United States: Oxford University Press

Erscheinungsjahr

2019

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Human immunodeficiency virus (HIV)-infected persons are at a higher risk of severe influenza. Although we have shown that a standard-dose intradermal influenza vaccine versus a standard-dose intramuscular influenza vaccine does not result in differences in hemagglutination-inhibition titers in this population, a comprehensive examination of cell-mediated immune responses remains lacking. Serological, antigen-specific B-cell, and interleukin 2-, interferon γ-, and tumor necrosis factor α-secreting T-cell responses were assessed in 79 HIV-infected men and 79 HIV-uninfected men. The route of vaccination did not affect the immunoglobulin A and immunoglobulin G (IgG) plasmablast or memory B-cell response, although these were severely impaired in the group with a CD4+ T-cell count of <200 cells/μL. The frequencies of IgG memory B cells measured on day 28 after vaccination were highest in the HIV-uninfected group, followed by the group with a CD4+ T-cell count of ≥200 cells/μL and the group with a CD4+ T-cell count of <200 cells/μL. The route of vaccination did not affect the CD4+ or CD8+ T-cell responses measured at various times after vaccination. The route of vaccination had no effect on antibody responses, antibody avidity, T-cell responses, or B-cell responses in HIV-infected or HIV-uninfected subjects. With the serological and cellular immune responses to influenza vaccination being impaired in HIV-infected individuals with a CD4+ T-cell count of <200 cells/μL, passive immunization strategies need to be explored to protect this population. NCT01538940.