Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Correlation of K-ras Gene Mutations with the Protein Expressions of TAK1 and MAP4K2 in Colorectal Cancer
Ist Teil von
Sichuan da xue xue bao. Journal of Sichuan University. Yi xue ban, 2019-01, Vol.50 (1), p.61-65
Ort / Verlag
China
Erscheinungsjahr
2019
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
To analyze the correlation of
gene mutations with the protein expressions of transforming growth factor-β activating kinase 1 (TAK1) protein and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2) protein in colorectal cancer.
gene mutations were detected by DNA sequencing analysis, and the expressions of TAK1 protein and MAP4K2 protein were detected by immunohistochemical method in 76 cases of colorectal cancer tissues.
In 76 cases of colorectal cancer tissues, the mutation rate of
gene was 32.89% (25 cases), and
gene mutations were correlated with the degrees of cell differentiation (
<0.05). The positive rates of TAK1 protein and MAP4K2 protein were 48.68% and 46.05%, respectively. The protein expressions of TAK1 and MAP4K2 were positively correlated with the degrees of cell differentiation and lymph node metastases, respectively (
<0.05). There was no correlation between
gene mutation and either TAK1 protein or MAP4K2 protein expression (
>0.05). In 25 cases of colorectal cancer with
mutation