Details

Autor(en) / Beteiligte

• Hinkes, Stefan P. A
• Klein, Christian D. P

Titel

Virtues of Volatility: A Facile Transesterification Approach to Boronic Acids

Ist Teil von

• Organic letters, 2019-05, Vol.21 (9), p.3048-3052

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2019

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Boronic acids are an increasingly important compound class for many applications, including C–C bond formation reactions, medicinal chemistry, and diagnostics. The deprotection of boronic ester intermediates is frequently a problematic and inefficient step in boronic acid syntheses. We describe an approach that highly facilitates this transformation by leveraging the volatility of methylboronic acid and its diol esters. The method is performed under mild conditions, provides high yields, and eliminates cumbersome and problematic purification steps.