Details

Autor(en) / Beteiligte

• Chen, Yong
• Li, Zheng-quan
• Deng, Yuan-qiang
• Yu, Bing-ying
• Pan, Wen-long
• Song, Hua-can

Titel

Synthesis and Photodynamic Activity of Peri-xanthenoxanthene Derivatives

Ist Teil von

• Chemical and Pharmaceutical Bulletin, 2019/07/01, Vol.67(7), pp.690-692

Ort / Verlag

Japan: The Pharmaceutical Society of Japan

Erscheinungsjahr

2019

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Photodynamic therapy (PDT) is a modern cancer therapy. But it is still difficult to obtain ideal photosensitizers. We synthesized six new peri-xanthenoxanthene derivatives rapidly and efficiently using solid-phase carbon-bath microwave irradiation technology, and investigated their in vitro photodynamic antitumor activity with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Our results showed that all compounds exhibited extremely low dark cytotoxicity and good phototoxicity against four human cancer cell lines. In particular, compound 3c showed the best in vitro PDT activity against Hela cells and Bel-7402 cells with IC50 values of 91 and 74 nmol/L, respectively. Its value of 1-octanol/water partition coefficient (log Kow) was 0.5309, suggesting that it is a promising photosensitizer for PDT due to its low dark cytotoxicity, high phototoxicity, and potential water solubility.