Details

Autor(en) / Beteiligte

• Li, Mu-Yang
• Zhu, Xin-Ming
• Niu, Xiao-Tian
• Chen, Xiu-Mei
• Tian, Jia-Xin
• Kong, Yi-Di
• Zhang, Dong-Ming
• Zhao, Lei
• Wang, Gui-Qin

Titel

Effects of dietary Allium mongolicum Regel polysaccharide on growth, lipopolysaccharide-induced antioxidant responses and immune responses in Channa argus

Ist Teil von

• Molecular biology reports, 2019-04, Vol.46 (2), p.2221-2230

Ort / Verlag

Dordrecht: Springer Netherlands

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• The present study evaluated the effects of dietary Allium mongolicum Regel polysaccharide (AMRP) on growth, lipopolysaccharide-induced antioxidant responses and immune responses in Channa argus . A basal diet was supplemented with AMRP at 0, 1, 1.5 or 2 g/kg feed for 56 days. After the 56 days feeding period, weight gain (WG), specific growth rate (SGR) and feed conversion ratio (FCR) were significantly increased or decreased ( P  < 0.05) by dietary AMRP, with the highest WG, SGR and the minimum FCR occurring in 1.5 g/kg AMRP group. Furthermore, AMRP supplementation conferred significant protective effects against LPS challenge by preventing alterations in the levels of complements 3 (C3) and complements 4 (C4), lysozyme, superoxide dismutase (SOD), glutathione-S-transferase (GST), interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α) while regulating the expression of immune-related genes including heat shock protein 70 (HSP70), heat shock protein 90 (HSP90), SOD, GST, IL-1 and TNF-α. Finally, AMRP supplementation significantly increased serum total protein, albumin and globulin concentrations and reduced mortality after LPS challenge. Taken together, our results suggest that the administration of AMRP could attenuate LPS-induced negative effects in C. argus , with 1.5 g/kg considered a suitable dose.