Details

Autor(en) / Beteiligte

• Tanaka, Atsushi

Titel

Emerging novel treatments for autoimmune liver diseases

Ist Teil von

• Hepatology research, 2019-05, Vol.49 (5), p.489-499

Ort / Verlag

Netherlands: Wiley Subscription Services, Inc

Erscheinungsjahr

2019

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• The etiology of autoimmune liver diseases, such as autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC), still remains largely unknown and no therapeutic agents that are able to “cure” these diseases have been developed. Although corticosteroids for AIH and ursodeoxycholic acid for PBC have been shown to significantly improve liver transplantation (LT)‐free survival and are recommended as first‐line drugs, treatment strategies for patients who show incomplete response to these drugs have not yet been fully established. No drug is significantly associated with long LT‐free survival in PSC patients. Nevertheless, with progress in genetics, immunology, and cellular biology, several new compounds or antibodies are expected to have an effect on autoimmune liver diseases and several drugs are under consideration for clinical use. Although most clinical trials have been carried out in the USA or Europe, some are, or will be, undertaken in Japan in the future. In this review, the current standard‐of‐care of autoimmune liver diseases will be summarized, together with emerging novel treatments relevant to clinical practice in Japan.