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BibTeX
Decellularized human liver scaffold‐based three‐dimensional culture system facilitate hepatitis B virus infection
Journal of biomedical materials research. Part A, 2019-08, Vol.107 (8), p.1744-1753
Zhang, ZhenZhen
Xu, HongMei
Mazza, Giuseppe
Zhang, MingMan
Frenguelli, Luca
Liu, QuanBo
Al‐Akkad, Walid
Ren, JiHua
Zhao, RuiQiu
Ren, Fang
Chen, Xin
Huang, AiLong
Chen, Juan
2019
Details
Autor(en) / Beteiligte
Zhang, ZhenZhen
Xu, HongMei
Mazza, Giuseppe
Zhang, MingMan
Frenguelli, Luca
Liu, QuanBo
Al‐Akkad, Walid
Ren, JiHua
Zhao, RuiQiu
Ren, Fang
Chen, Xin
Huang, AiLong
Chen, Juan
Titel
Decellularized human liver scaffold‐based three‐dimensional culture system facilitate hepatitis B virus infection
Ist Teil von
Journal of biomedical materials research. Part A, 2019-08, Vol.107 (8), p.1744-1753
Ort / Verlag
Hoboken, USA: John Wiley & Sons, Inc
Erscheinungsjahr
2019
Link zum Volltext
Quelle
Wiley Online Library
Beschreibungen/Notizen
Hepatitis B virus (HBV) study is hampered by lacking of idea cell model which support effective HBV infection and meanwhile recapitulate hepatocyte biology function in vivo. In this study, we developed decellularized human liver scaffolds for cell culture and further applied for HBV infection. As a result, primary human hepatocytes (PHHs) engrafted into liver scaffolds and maintained differentiation with stable albumin secretion and liver‐specific gene expression. Comparing to mono‐layer cell culture, scaffold‐based three‐dimensional (3D) culture system significantly augment HBV DNA (including cccDNA), RNA level as well as HBsAg secretion. Moreover, HepG2‐NTCP cells cultured on 3D system exhibited higher infection efficiency and longer infection period in vitro. In addition, HBV DNA level was suppressed when anti‐HBV medicine Entecavir (ETV) introduced into HepG2‐NTCP 3D system. Herein, we evaluated the potential of decellularized human liver scaffold‐based in 3D cell culture and disclosed that scaffold‐based 3D culture system can facilitate HBV infection in vitro. This 3D culture system could be further applied in HBV‐related study. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1744–1753, 2019.
Sprache
Englisch
Identifikatoren
ISSN: 1549-3296
eISSN: 1552-4965
DOI: 10.1002/jbm.a.36690
Titel-ID: cdi_proquest_miscellaneous_2206225839
Format
–
Schlagworte
3D culture
,
Biotechnology
,
Cell culture
,
decellularized human liver scaffold
,
Deoxyribonucleic acid
,
DNA
,
Gene expression
,
Hepatitis
,
Hepatitis B
,
Hepatitis B surface antigen
,
hepatitis B virus
,
Hepatocytes
,
In vivo methods and tests
,
Infections
,
Liver
,
Ribonucleic acid
,
RNA
,
Scaffolds
,
Secretion
,
Viruses
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